Total Knee Replacement Market By Procedure Type (Primary Knee Replacement, Revision Knee Replacement, Partial Knee Replacement), By Device Type (Three-compartmental knee implants, Bicompartmental knee implants, Unicompartmental knee implants), By Implant Type (Fixed-Bearing Implants, Mobile-Bearing Implants, Posterior-Stabilized Implants, Cruciate-Retaining Implants), By Material Type (Metal-on-Polyethylene, Ceramic-on-Polyethylene, Ceramic-on-Ceramic, Metal-on-Metal, Other), By Fixation Method (Cemented Fixation, Cementless Fixation, Hybrid Fixation), By End-User (Hospitals, Ambulatory Surgical Centers, Orthopedic Clinics), Global Market Size, Segmental analysis, Regional Overview, Company share analysis, Leading Company Profiles And Market Forecast, 2025 – 2035

Industry Outlook

The total Knee Replacement market accounted for USD 10.2 Billion in 2024 and is expected to reach USD 18.0 Billion by 2035, growing at a CAGR of around 5.3% between 2025 and 2035. The Total Knee Replacement Market is poised for significant growth shortly considering the progress made in surgical technologies, the increasing aging population, and the increasing incidences of knee diseases like osteoarthritis and rheumatoid arthritis.

The increasing use of robots in surgeries and the use of customized implants made via 3D printers are improving the accuracy of surgeries as well as patient welfare through value additions hence making new markets for the industry. Besides, knowledge about joint replacement surgeries, and better healthcare accessibility across the world especially in developing nations, are also driving factors. Nevertheless, barriers like high implant cost, low insurance coverage across certain parts of the world, and risks of complications related to surgery could slow down market advancements. Strategic sourcing is now done based on innovation, collaborations, and location since key players need to sustain competition.

Report Scope:

Market Dynamics

Aging Population Increases Demand for Knee Replacement Surgeries

The key factor that is most influential to the Total Knee Replacement Market is the global aging population. A person’s chance of developing osteoarthritis or other degenerative joint diseases increases between seventy and eighty years, leading to chronic pain, disability, and later knee replacement surgery. Knee problems are also common with seniors because their body’s cells are aging which implies that their body cells are older and their bones have worn out or rubbed off respectively on the knee joint. Due to this demographic shift, there is continued adoption of Total Knee Replacement procedures in the market thus driving its growth.

Secondly, with the improvement of medical care and the increase in the average length of life, more elderly people come into the category of candidates for knee replacements. With the increase of elderly people, especially in North America and Europe, the requirement for total knee replacement surgery will also increase, which is expected to bring the market more development.

Technological Advancements Improve Surgical Outcomes and Efficiency

With the advancement in technology, the Total Knee Replacement Market has undergone a drastic change and made the surgeries safer, efficient, and mostly less invasive. Consequently, novel trends in robotic surgery comprise precision, shorter recovery periods, and better patient experience. These innovations enable the surgeon to edit an incision to reduce the time for the patient’s healing as well as improve the prosthetic knee alignment. Further, the research also found that through improved 3D printing techniques, knee implants can be produced to fit each patient in terms of his or her body anatomy, hence improving the length of the implant. Because these technologies provide more reasonable costs to patients, more people demand knee replacement surgeries, leading to an improvement in patient satisfaction.

Post-Surgical Complications May Affect Long-Term Success Rates

Although the Total Knee Replacement Market is witnessing general success in knee replacement surgeries, issues related to post-surgical complications remain a major concern. They may get infections, formation of blood clots, failure of implants, or continue having pain after surgery among other complications that make them have a less than desired result. Such complications are not limited to the patient’s recovery process but can also raise the amount of money a patient needs to spend on his or her treatment processes, follow-ups, or further surgeries. It is nevertheless important to emphasize that complications despite better surgical and implant technologies remain a reality. They may therefore avoid going for the procedure or delay it, thus slowing the sector’s expansion and the more extended market impact.

Adoption of Robotic-Assisted Surgeries Enhances Surgical Precision

The increasing trend of robotic-assisted knee replacement surgery is another attractive trend in the Total Knee Replacement Market. Self-guiding systems provide improved accuracy in anchorage and guarantee better results in the long run and lower risks of failures. Thus, greater precision in making incisions can be achieved complemented with more accurate placement of the implant than in using traditional means. This not only results in better post-surgery recovery and shorter hospital stays but also makes the surgery more attractive to many patients. With technological advancement coupled with the availability of cheap robotic technology in the market, robotic systems will be adopted by other health facilities thereby creating another revenue model for firms that deal with the provision of robotic surgical equipment and related services.

Expansion of Healthcare Infrastructure in Emerging Markets.

Upcoming nations have made for the total knee replacement market as the growth of healthcare facilities in developing countries including India, China, and Brazil. These populations are enjoying fast economic growth which has resulted in better standards of living, and better access to enhanced health care. As a consequence, demand for knee replacements in these regions is slowly increasing because more people are becoming financially capable of going for surgeries.

Further, the governments and private healthcare segment of various countries and regions are investing heavily in establishing modern technologically advanced medical centers and projected growth in the number of surgeries is anticipated. The development of this robust healthcare system will create a favorable environment for the performance of Total Knee Replacement and the adoption of newer technologies, thus giving rise to robust avenues of growth in the Total Knee Replacement industry spread across these developing economies.

Industry Experts Opinion

"Total Knee Replacement remains one of the most successful orthopedic procedures for patients with advanced osteoarthritis or joint degeneration. With advances in implant technology and minimally invasive surgical techniques, we are achieving better alignment and faster recovery times. The key challenge moving forward is ensuring long-term durability of the implants and optimizing recovery for patients of all ages."

• Dr. Thomas M. Holtz, MD, Orthopedic Surgeon and Director of Joint Replacement, Mayo Clinic

"TKR surgery has seen significant improvements in both surgical techniques and prosthetic materials over the past few decades. However, the focus is shifting toward developing more personalized treatments through technologies like 3D printing for customized implants and the potential for biological therapies, such as stem cell treatments, to enhance healing and possibly reduce the need for future revisions."

• Sir Bruce P. McGregor, Professor, Chair of Orthopedic Surgery, University of Oxford

Segment Analysis

Based on Procedure Type, the segment of primary knee replacement holds the largest share in the total knee replacement market because it is the first surgical option for patients with osteoarthritis or other severe conditions of the knee joint. It represents the largest procedures done across the globe thanks to increased surgical knowledge and skills, rising incidences of knee disorders, and improved sensitization among patients on the efficiency of early surgical operations. The simplicity of primary knee replacement compared to revision surgeries also makes it cheaper hence affordable to the patient its high demand by hospitals and orthopedic clinics.

Based on Implant Type, the market’s well-known Fixed-Bearing Implants segment holds immense profits, considering the extended applicability of Fixed-Bearing Implant across broad categories of patients and greater life spans. These implants are favored by surgeons for their basic geometry, relative ease in implantation, and favorable long-term outcomes in improving pain and function. Fixed-bearing implants are especially useful in elderly or inactive individuals because they dovetail, meaning they don’t wear and are highly supportive. They are accessible and inexpensive implants making them widely used implants within the developed and emerging markets cementing their position within the implant niche market.

Regional Analysis

North America Market occupies the largest share which has high indicators of the development of the healthcare sector, high spending on healthcare, and an increased life expectancy. Knee-related issues like osteoarthritis are more predominant in this area and hence are the drivers of knee replacement surgeries. Overall, North America has more progress using innovative instruments including robotic-based MIS surgical tools, and patient-customized implants that improve intraoperative accuracy and effectiveness of surgeries.

Positive reimbursement policies and the increased dominance of major market players such as Stryker, Zimmer Biomet, and DePuy Synthes are also driving this market. Also, constant increases in awareness among patients and healthcare workers about knee replacement options put steady market demand in place; thus, North America is the largest regional Knee Replacement Market.

The Asia-Pacific region is the most rapidly developing segment in the Total Knee Replacement Market primarily due to the sizeable growth in demand caused by population aging, the increasing health awareness among people, and enhanced availability of qualified healthcare services. Several developing countries such as India, China, and Indonesia show a growing demand for knee replacement medical procedures owing to an increasing middle-income population and rising levels of per capita income.

International clients find the geographic area offering affordable surgical procedures and increasing medical tourism in the area. Further, factors like the raised concern of governments for improving the health care framework and integration of advanced technologies and techniques like robotic-aided surgeries are catalyzing the growth of the market. With healthcare institutions in the region expanding their capacity through the purchase of advanced technology equipment Asia-Pacific is likely to emerge as a growth market in Total Knee Replacement.  

Competitive Landscape

The Total Knee Replacement Market is highly competitive, with key players focusing on innovation, strategic partnerships, and geographic expansion to maintain their market positions. Major companies like Zimmer Biomet, Stryker Corporation, DePuy Synthes (Johnson & Johnson), and Smith & Nephew dominate the market through their extensive product portfolios and global presence. These players are also emphasizing growth in research and development to come up with new implants including patient-specific and robotic-assisted systems to improve surgical accuracy and thus the patients’ results.

Also, there are new market entrants in place, both, local and small-scale players that can provide affordable solutions in response to the increased demand in developing countries. They are also geared by technology with 3D printing and minimally invasive techniques challenging the market competition. With the manufacturing companies aware of the rising demand for better-performing cost-effective implants in the market, competitors are using cost leadership strategies and exploring new markets.

Total Knee Replacement Market, Company Shares Analysis, 2024

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Recent Developments:

• In August 2024, Zimmer Biomet Holdings reported higher-than-expected profits for the second quarter, driven by increased demand for joint reconstruction devices, including those used in total knee replacements
• In June 2024, VELYS Robotic-Assisted Solution was cleared by the 510(k) FDA for clinical use in the Unicompartmental Knee Arthroplasty to DePuy Synthes. It is believed that this approval will expand the company’s recognition and its stance in the market.

Report Coverage:

By Procedure Type

• Primary Knee Replacement
• Revision Knee Replacement
• Partial Knee Replacement

By Device Type

• Three-compartmental knee implants
• Bicompartmental knee implants
• Unicompartmental knee implants

By Implant Type

• Fixed-Bearing Implants
• Mobile-Bearing Implants
• Posterior-Stabilized Implants
• Cruciate-Retaining Implants

By Material Type

• Metal-on-Polyethylene
• Ceramic-on-Polyethylene
• Ceramic-on-Ceramic
• Metal-on-Metal
• Other

By Fixation Method

• Cemented Fixation
• Cementless Fixation
• Hybrid Fixation

     By End-User

• Hospitals
• Ambulatory Surgical Centers (ASCs)
• Orthopedic Clinics

By Region

North America

• U.S.
• Canada

Europe

• U.K.
• France
• Germany
• Italy
• Spain
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• Australia
• South Korea
• Singapore
• Rest of Asia Pacific

Latin America

• Brazil
• Argentina
• Mexico
• Rest of Latin America

Middle East & Africa

• GCC Countries
• South Africa
• Rest of the Middle East & Africa

List of Companies:

• Zimmer Biomet
• Stryker Corporation
• DePuy Synthes
• Smith & Nephew
• Medtronic
• B. Braun Melsungen AG
• Conformis, Inc.
• MicroPort Scientific Corporation
• Exactech, Inc.
• Corin Group
• DJO Global
• Wright Medical Group N.V.
• Aesculap Implant Systems
• Mathys AG Bettlach
• Arthrex, Inc

Frequently Asked Questions (FAQs)